| | | | | | | | | | |  | Major Transactions |
| | | | Thursday, October 14th, 1965 | | Placed 2B D. Menke on the 60-day disabled list. | | Placed RF H. Bedell on the active roster. | | Placed 2B D. Menke on the 60-day disabled list. | | Placed RF H. Bedell on the active roster. |
| Sunday, June 27th, 1965 | | Placed MR J. Constable on the 60-day disabled list. | | Placed MR H. Fischer on the active roster. |
| Wednesday, May 5th, 1965 | | Signed 3B J. Torre to a 3-year contract extension worth a total of $2,640,600. |
| Tuesday, April 27th, 1965 | | Signed SS H. Kuenn to a 3-year contract extension worth a total of $2,542,800. |
| Monday, April 26th, 1965 | | Signed SP D. Nottebart to a 3-year contract extension worth a total of $1,622,400. |
| Thursday, April 22nd, 1965 | | Signed CL C. Raymond to a 2-year contract extension worth a total of $773,200. |
| Thursday, April 15th, 1965 | | Signed C D. Pavletich to a 4-year contract extension worth a total of $2,151,200. |
| Monday, March 15th, 1965 | | Signed free agent MR G. Bell to a 1-year contract worth a total of $23,390. | | Signed free agent 1B H. Bright to a 1-year contract worth a total of $69,200. | | Signed free agent MR H. Score to a 1-year contract worth a total of $33,400. | | Placed 1B H. Bright on the active roster. | | Demoted LF H. Taylor to Triple A Toronto. | | Demoted 3B L. Klimchock to Triple A Toronto. | | Placed MR H. Score on the active roster. | | Placed MR G. Bell on the active roster. |
| Wednesday, December 16th, 1964 | | Placed RF F. Valentine on the active roster. |
| Thursday, December 10th, 1964 | | Signed free agent RF F. Valentine to a 2-year contract worth a total of $78,400. |
| Thursday, November 19th, 1964 | | SP R. Terry becomes a free-agent. | | SP B. Heffner received a 1-year contract through automatic renewal worth a total of $23,390. | | MR A. Gatewood received a 1-year contract through automatic renewal worth a total of $23,390. | | MR D. Eilers received a 1-year contract through automatic renewal worth a total of $23,390. | | MR K. Sanders received a 1-year contract through automatic renewal worth a total of $23,390. | | C B. Uecker received a 1-year contract through automatic renewal worth a total of $23,390. | | 3B T. Kubek becomes a free-agent. | | 1B H. Bright becomes a free-agent. | | MR H. Score becomes a free-agent. | | RF R. Staub received a 1-year contract through automatic renewal worth a total of $23,390. | | LF W. Horton received a 1-year contract through automatic renewal worth a total of $23,390. |
| Monday, November 16th, 1964 | | 2B D. Menke received a 1-year contract through arbitration worth a total of $61,410. | | SP B. Hendley received a 1-year contract through arbitration worth a total of $278,452. | | 1B D. Pavletich received a 1-year contract through arbitration worth a total of $265,300. | | SP D. Nottebart received a 1-year contract through arbitration worth a total of $278,640. | | CL C. Raymond received a 1-year contract through arbitration worth a total of $318,840. | | C J. Torre received a 1-year contract through arbitration worth a total of $492,100. |
| Sunday, November 1st, 1964 | | Signed 3B E. Charles to a 3-year contract extension worth a total of $119,400. |
| Saturday, October 31st, 1964 | | Signed MR D. Radatz to a 2-year contract extension worth a total of $76,800. |
| Tuesday, October 27th, 1964 | | RF B. Cerv retires. |
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